Mac and Cheese Meatloaf Casserole combines two classic comfort foods into one delicious dish. This hearty recipe features a meaty base topped with rich, cheesy macaroni, making it a family favorite. Perfect for busy weeknights or cozy gatherings, this casserole packs flavor, texture, and a touch of nostalgia in every bite.

Why Make This Recipe
If you’re wondering why you should dive into this Mac and Cheese Meatloaf Casserole, here are a few compelling reasons:
Easy Preparation: This recipe is straightforward and doesn’t require advanced cooking skills. The ingredients are simple, and the steps are easy to follow.
Family-Friendly: Kids and adults alike will love the mixture of flavors. The combination of meatloaf and macaroni and cheese is sure to satisfy even the pickiest eaters.
Makes Great Leftovers: You can easily make a big batch and enjoy leftovers for lunch or dinner the next day. The flavors only get better as they meld together.
Versatile: You can customize this casserole according to your family’s tastes. Add veggies, change the cheese, or even swap out meats to create your own version.
Budget-Friendly: Utilizing basic ingredients keeps this meal affordable, making it easy to feed a crowd without breaking the bank.

How to Make Mac and Cheese Meatloaf Casserole
Let’s get into how to whip up this fantastic dish. Here’s what you’ll need and how to prepare it.
Ingredients
For the Mac and Cheese Meatloaf Casserole, you’ll need:
- 1 1⁄2 pounds ground beef
- 1 cup breadcrumbs
- 1 egg
- 1⁄2 cup milk
- 1 small onion, finely chopped
- 1 teaspoon garlic powder
- 1 teaspoon salt
- 1⁄2 teaspoon black pepper
- 1⁄2 cup barbecue sauce (for topping)
- 2 cups macaroni
- 2 cups cheddar cheese, shredded
- 2 cups milk (for mac and cheese)
- 1 teaspoon mustard
- 1/2 teaspoon paprika

Instructions
Preheat your oven to 375°F (190°C). This ensures even cooking for the casserole.
In a large mixing bowl, combine the ground beef, breadcrumbs, egg, 1⁄2 cup milk, chopped onion, garlic powder, salt, and black pepper. Mix well until fully blended.
Press the meat mixture into the bottom of a greased casserole dish, forming a solid layer.
Bake the meatloaf layer for 30 minutes. While it bakes, you can prepare the macaroni and cheese.
Cook the macaroni according to package instructions. Once cooked, drain it and return it to the pot.
Stir in 2 cups of milk, cheddar cheese, mustard, and paprika into the macaroni. Mix until the cheese is melted and everything is well combined.
Carefully pour the creamy mac and cheese over the baked meatloaf layer.
Drizzle the top with barbecue sauce, then return the dish to the oven.
Bake for an additional 20 minutes or until the entire dish is heated through.
Allow the casserole to cool for a few minutes before serving. Enjoy your cheesy, meaty creation!
How to Serve Mac and Cheese Meatloaf Casserole
Serve Mac and Cheese Meatloaf Casserole as a standalone dish since it’s filling and hearty on its own. Pair it with a light green salad or steamed vegetables for a complete meal. This dinner option works well for casual family dinners and potlucks, showcasing a well-loved classic that everyone can enjoy.
How to Store Mac and Cheese Meatloaf Casserole
It’s simple to store leftovers of this casserole, allowing you to savor the delicious flavors later:
Refrigeration: Once cooled, cover the casserole tightly with plastic wrap or aluminum foil, or transfer it to an airtight container. It can be stored in the fridge for up to 3-4 days.
Freezing: You can freeze portions of the casserole. Cut them into individual servings, wrap tightly, and store in freezer-safe bags or containers. It can last up to 2-3 months in the freezer. Thaw in the refrigerator before reheating.
Tips for Success with Mac and Cheese Meatloaf Casserole
Don’t Overmix the Meat: When you combine the meatloaf ingredients, mix them just until everything is incorporated. Overmixing can lead to a dense meatloaf.
Customize the Cheese: Feel free to experiment with different types of cheese like pepper jack, mozzarella, or crushed cheese crackers on top for added flavor.
Add Veggies: For extra nutrition, consider adding finely chopped vegetables such as bell peppers or spinach to the meatloaf mixture.
Check for Doneness: Use a meat thermometer to ensure the meatloaf reaches an internal temperature of 160°F for safety.
Variations
Spicy Version: Add diced jalapeños or red pepper flakes for a bit of heat.
BBQ Twist: Mix BBQ sauce into the meatloaf mixture for a different flavor profile.
Vegetarian Style: Substitute ground beef with lentils, chickpeas, or a store-bought meat alternative. Use plant-based milk and cheese to make it vegetarian-friendly.
Frequently Asked Questions
Can I prepare this casserole in advance?
Yes, you can prepare the meatloaf and macaroni layers a day in advance. Just assemble and bake it when you’re ready to serve!
How can I reheat leftovers?
For the best results, reheat the casserole in the oven at 350°F until warmed through. You can also use the microwave, but it may not maintain the same texture.
Can I add other ingredients to the casserole?
Absolutely! Feel free to add diced mushrooms, bell peppers, or other proteins like bacon or sausage for added flavor.
With this Mac and Cheese Meatloaf Casserole, you’re not just cooking a meal; you’re creating a hearty and comforting experience that will bring together family and friends around the dinner table. Whether it’s a weeknight dinner or a special occasion, this dish is sure to please everyone. For more delicious casserole recipes, check out our Website!